MC1R variants are established risk factors of melanoma. These genetic variants lead to the production of the less protective pheomelanin in melanocytes of the skin, thereby leading to rather fair skin and often to red hair. Now, Prof. Okamoto and his team find out that risk is different between females and males.
MC1R variants increase risk in females much more than in males
Not everyone who harbors these so called „red hair variants“ carries actually red hair (see also news from 12.8.2016 and 14.9.2016). Therefore, risk is independent of the actual hair color. This work was published in the number one scientific journal in the field of dermatology JAMA dermatology (impact factor=8.107):
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